Quarterly report pursuant to Section 13 or 15(d)

Stockholders' Equity (Details 5)

v3.5.0.2
Stockholders' Equity (Details 5) - $ / shares
 9 Months Ended 12 Months Ended
Sep. 30, 2016
Dec. 31, 2015
Weighted Average Remaining Contractural Life - Years 7 years 6 months 11 days 7 years 3 months 11 days
Number of options outstanding 1,451,861 1,047,450
Weighted Average Exercise Price Stock Options Outstanding $ 9.41 $ 18.50
Number of Awards Vested 756,162 688,452
Weighted Average Exercise Price $ 13.36 $ 24.75
Weighted Average Remaining Contractual Life of Stock Options Vested 6 years 4 months 6 days 6 years 5 months 16 days
Range One [Member]    
Exercise price lower range limit $ 1.74 $ 4.15
Exercise price upper range limit $ 4.50 $ 6.30
Weighted Average Remaining Contractural Life - Years 6 years 10 months 24 days 9 years 8 months 12 days
Number of options outstanding 9,993 698,323
Weighted Average Exercise Price Stock Options Outstanding $ 3.25 $ 5.38
Number of Awards Vested 9,993 393,145
Weighted Average Exercise Price $ 3.25 $ 5.31
Weighted Average Remaining Contractual Life of Stock Options Vested 6 years 10 months 24 days 9 years 6 months 29 days
Range Two [Member]    
Exercise price lower range limit $ 4.51 $ 12.75
Exercise price upper range limit $ 6.00 $ 25.00
Weighted Average Remaining Contractural Life - Years 9 years 1 month 21 days 3 years 3 months 4 days
Number of options outstanding 812,033 129,141
Weighted Average Exercise Price Stock Options Outstanding $ 4.60 $ 15.52
Number of Awards Vested 227,318 75,321
Weighted Average Exercise Price $ 4.60 $ 17.50
Weighted Average Remaining Contractual Life of Stock Options Vested 9 years 1 month 21 days 3 years 2 months 12 days
Range Three [Member]    
Exercise price lower range limit $ 6.01 $ 25.05
Exercise price upper range limit $ 20.00 $ 64.50
Weighted Average Remaining Contractural Life - Years 6 years 9 months 3 years 14 days
Number of options outstanding 451,843 133,648
Weighted Average Exercise Price Stock Options Outstanding $ 7.61 $ 37.93
Number of Awards Vested 340,849 133,648
Weighted Average Exercise Price $ 7.53 $ 37.93
Weighted Average Remaining Contractual Life of Stock Options Vested 6 years 7 months 21 days 3 years 14 days
Range Four [Member]    
Exercise price lower range limit $ 20.01 $ 67.50
Exercise price upper range limit $ 45.00 $ 94.50
Weighted Average Remaining Contractural Life - Years 2 years 5 months 27 days 7 months 17 days
Number of options outstanding 144,683 38,338
Weighted Average Exercise Price Stock Options Outstanding $ 31.47 $ 73.77
Number of Awards Vested 144,683 38,338
Weighted Average Exercise Price $ 31.47 $ 73.77
Weighted Average Remaining Contractual Life of Stock Options Vested 2 years 5 months 27 days 7 months 17 days
Range Five [Member]    
Exercise price lower range limit $ 45.01 $ 96.00
Exercise price upper range limit $ 73.50 $ 119.25
Weighted Average Remaining Contractural Life - Years 11 months 12 days 1 month 13 days
Number of options outstanding 33,309 48,000
Weighted Average Exercise Price Stock Options Outstanding $ 57.13 $ 119.25
Number of Awards Vested 33,309 48,000
Weighted Average Exercise Price $ 57.13 $ 119.25
Weighted Average Remaining Contractual Life of Stock Options Vested 11 months 12 days 1 month 13 days